Therapeutic Effect of Milk Thistle (Silybum Marianum L) Seeds on Carbon Tetrachloride - Induced Hepatotoxicity in Rats
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چکیده
منابع مشابه
Milk Thistle (Silybum marianum)
Milk thistle is a well known and commonly used herb, used particularly in hepatic diseases. It has very potent antioxidant, anti-inflammatory, and antifibrotic properties (1). As a single agent its therapeutic effects in liver disease appear to be modest (2,3,4,5). Herbal medicines and supplements are likely to be much more beneficial when used synergistically in combinations or formulas. Milk ...
متن کاملEffect of Silybum marianum on acute hepatic damage caused by carbon tetrachloride in rats
The study was designed to test the efficiency of of Silybum marianum in different doses to treat carbon tetrachloride (CCl4) induced liver damage. Thirty-five Wistar albino rats were divided randomly into five groups as follows: Control Group: 4 ml saline; CCl4 Group: 4 ml saline plus 2 ml/kg CCl4; 2.5% Infusion Group: 2 ml/kg CCl4 plus 2.5% infusion of Silybum marianum; 5% Infusion Group: 2 ml...
متن کاملHepatoprotective Effect of Silymarin (Silybum marianum) on Hepatotoxicity Induced by Acetaminophen in Spontaneously Hypertensive Rats
This study was aimed to investigate the effect of Silymarin (SLM) on the hypertension state and the liver function changes induced by acetaminophen (APAP) in spontaneously hypertensive rat (SHR). Animals normotensive (N) or hypertensive (SHR) were treated or not with APAP (3 g/kg, oral) or previously treated with SLM. Twelve hours after APAP administration, plasmatic levels of liver function ma...
متن کاملEffect of milk thistle (Silybum marianum) on the pharmacokinetics of irinotecan.
PURPOSE Milk thistle (Silybum marianum) is one of the most commonly used herbal therapies, and its principal constituent silybin significantly inhibits cytochrome P450 isoform 3A4 (CYP3A4) and UDP glucuronosyltransferase isoform 1A1 (UGT1A1) in vitro. Here, we investigated whether milk thistle affects the pharmacokinetics of irinotecan, a substrate for CYP3A4 and UGT1A1, in humans. EXPERIMENT...
متن کاملSilybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)-Chemistry, Bioavailability, and Metabolism.
Milk thistle (Silybum marianum) is a medicinal plant that has been used for thousands of years as a remedy for a variety of ailments. The main component of S. marianum fruit extract (silymarin) is a flavonolignan called silybin, which is not only the major silymarin element but is also the most active ingredient of this extract, which has been confirmed in various studies. This compound belongs...
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ژورنال
عنوان ژورنال: Alexandria Science Exchange Journal
سال: 2019
ISSN: 2536-9784
DOI: 10.21608/asejaiqjsae.2019.26436